What is a clone?
- A clone refers to a population of cells or organisms derived asexually from a single ancestor
- Dolly was the world’s FIRST mammalian clone
- An adult mammalian cell was reprogrammed produce a complete viable organism
Dolly & her Creator lan Wilmut :
Cloned mammals :
- Snuppy is the latest mammal to be cloned after sheep, mice, cats, rats, cows, goats, pigs, horses, rabbits and a mule.
Seoul National University Puppy :
Somatic Cell Nuclear Transfer :
- Dolly the sheep was created using udder cell nucleus
- Snuppy the dog was created using ear cell nucleus
- In the Ist human cloning cumulus - cell nuclei were used
Identical twins are clones :
BRIEF HISTORY OF CLONING :
- 1830s Mathias Schleiden and Theodor Schwann proposed cell theory
- 1950 Robert Briggs and Thomas King (Institute of Cancer Research in Philadelphia) did first ever nuclear transplantation in the frog Rana pipiens. Used nuclei from embryos
- John Gurdon (England) used nuclei from intestinal cells from adults for transplantation
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